Inter-individual differences of 4-[4-(4-methylphenyl)-phenylmethoxy-1-piperidinyl]butyric acid disposition in rats: possible involvement of genetic polymorphism.

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Article

Inter-individual differences of 4-[4-(4-methylphenyl)-phenylmethoxy-1-piperidinyl]butyric acid disposition in rats: possible involvement of genetic polymorphism.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000

Takahara E, Nagata O, Kato H, Ohta S, Hirobe M

Abstract excerpt

Inter-individual differences of drug plasma concentration were recognized in outbred rats after an oral or intravenous administration of (+)-4-[4-(4-methylphenyl)phenylmethoxy-1-piperidinyl]butyric acid hydrochloride ((+)-MPPB). Rats could be divided into two phenotypes, the rapid metabolizing (RM) group and the slow metabolizing (SM) group. The hepatic clearance of RM-phenotyped Sprague-Dawley rats was about 10...

Topics

Administration, Oral
Animals
Benzhydryl Compounds
Chromatography, High Pressure Liquid
Female
Injections, Intravenous
Liver
Male
Mass Spectrometry
Microsomes, Liver

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Polymorphism, Genetic

Protein Binding

Rats

Rats, Sprague-Dawley

Spectrophotometry, Ultraviolet

Stereoisomerism

Source

Open in PubMed

Identifiers

PMID: 7835229

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7835229-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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