Article
Identification of a new variant CYP2D6 allele with a single base deletion in exon 3 and its association with the poor metabolizer phenotype.
Human molecular genetics - 1 Jun 1994
Saxena R, Shaw G L, Relling M V, Frame J N, Moir D T, Evans W E, Caporaso N, Weiffenbach B
Abstract excerpt
The human CYP2D6 gene codes for the enzyme, debrisoquine 4-hydroxylase, which metabolizes over 25 therapeutically important drugs. The inability to metabolize these drugs, which results in a 'poor metabolizer' (PM) phenotype, can be attributed, in some cases, to the presence of any of three previ...
Topics
- Alleles
- Base Sequence
- Case-Control Studies
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- DNA
- DNA Primers
- Exons
- Genetic Carrier Screening
- Genetic Variation
- Genotype
- Humans
- Lung Neoplasms
- Mixed Function Oxygenases