Article
A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity.
British journal of clinical pharmacology - 1 Dec 1996
Masimirembwa C, Persson I, Bertilsson L, Hasler J, Ingelman-Sundberg M
Abstract excerpt
1. The debrisoquine hydroxylase (CYP2D6) is polymorphically distributed. Not only are there differences in the proportions of extensive metabolisers to poor metabolisers in various ethnic groups, but there are also pronounced variations in the metabolic capacity among those classified as extensiv...
Topics
- Black People
- Cytochrome P-450 CYP2D6
- DNA
- Exons
- Genotype
- Humans
- Mutation
- Open Reading Frames
- Phenotype
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Zimbabwe