Article
The p21(RAS) farnesyltransferase alpha subunit in TGF-beta and activin signaling.
Science (New York, N.Y.) - 23 Feb 1996
Wang T, Danielson P D, Li B Y, Shah P C, Kim S D, Donahoe P K
Abstract excerpt
The alpha subunit of p21(RAS) farnesyltransferase (FNTA), which is also shared by geranylgeranyltransferase, was isolated as a specific cytoplasmic interactor of the transforming growth factor-beta (TGF-beta) and activin type I receptors with the use of the yeast two-hybrid system. FNTA interacts specifically with ligand-free TGF-beta type l receptor but is phosphorylated and released upon ligand binding....
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