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Article

BRCA Gene Structure and Function in Tumor Suppression

1 Jan 2010

Abstract excerpt

Germline mutations in the BRCA1 and BRCA2 genes are characterized by deficient repair of DNA double-strand breaks by homologous recombination. Defective DNA double-strand break repair has been not only implicated as a key contributor to tumorigenesis in mutation carriers but also represents a potential target for therapy. The transcriptional similarities between BRCA1-deficient tumors and sporadic tumors of the...

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PMID: 20164689
DOI: 10.1097/ppo.0b013e3181cf0204

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