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Article

Pharmacology of L-type Calcium Channels: Novel Drugs for Old Targets?

Current molecular pharmacology - 1 Jan 2015

Striessnig Jörg, Ortner Nadine J, Pinggera Alexandra

Abstract excerpt

Inhibition of voltage-gated L-type calcium channels by organic calcium channel blockers is a well-established pharmacodynamic concept for the treatment of hypertension and cardiac ischemia. Since decades these antihypertensives (such as the dihydropyridines amlodipine, felodipine or nifedipine) belong to the most widely prescribed drugs world-wide. Their tolerability is excellent because at therapeutic doses...

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Identifiers

PMID: 25966690
DOI: 10.2174/1874467208666150507105845
PMCID: PMC5384371

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