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Article

Receptor stimulation causes slow inhibition of IRK1 inwardly rectifying K+ channels by direct protein kinase A-mediated phosphorylation.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jun 1996

Wischmeyer E, Karschin A

Abstract excerpt

Strongly rectifying IRK-type inwardly rectifying K+ channels are involved in the control of neuronal excitability in the mammalian brain. Whole-cell patch-clamp experiments show that cloned rat IRK1 (Kir 2.1) channels, when heterologously expressed in mammalian COS-7 cells, are inhibited following the activation of coexpressed serotonin (5-hydroxytryptamine) type 1A receptors by receptor agonists. Inhibition is...

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Identifiers

PMID: 8650176
DOI: 10.1073/pnas.93.12.5819
PMCID: PMC39145

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Source receipt: pubmed, retrieved 7 Sept 2026.

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