Article
Behavioural alterations in male mice lacking the gene for D-aspartate oxidase.
Behavioural brain research - 10 Aug 2006
Weil Zachary M, Huang Alex S, Beigneux Anne, Kim Paul M, Molliver Mark E, Blackshaw Seth, Young Stephen G, Nelson Randy J, Snyder Solomon H
Abstract excerpt
D-serine and D-aspartate are important regulators of mammalian physiology. D-aspartate is found in nervous and endocrine tissue, specifically in hypothalamic supraoptic and paraventricular nuclei, pituitary, and adrenal medullary cells. Endogenous D-aspartate is selectively degraded by D-aspartate oxidase. We previously reported that adult male mice lacking the gene for D-aspartate oxidase (Ddo(-/-) mice) display...
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