Article
Behavioural anomalies in mice evoked by "Tokyo" disruption of the Vitamin D receptor gene.
Neuroscience research - 1 Apr 2006
Kalueff Allan V, Keisala Tiina, Minasyan Anna, Kuuslahti Marianne, Miettinen Susanna, Tuohimaa Pentti
Abstract excerpt
Vitamin D is a steroid hormone with many important functions in the brain, mediated through the nuclear Vitamin D receptor (VDR). Mounting clinical data link VDR mutations to various psychiatric phenotypes. We have reported previously that mutant mice lacking functional VDR ("Tokyo" VDR mutant mice) display several behavioural anomalies, including high anxiety and aberrant grooming. Given the important role of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
