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Article

Comprehensive behavioral analysis of indoleamine 2,3-dioxygenase knockout mice.

Neuropsychopharmacology reports - 1 Sept 2018

Hirata Nao, Hattori Satoko, Shoji Hirotaka, Funakoshi Hiroshi, Miyakawa Tsuyoshi

Abstract excerpt

AIM: Indoleamine 2,3-dioxygenase 1 (IDO1) metabolizes the essential amino acid tryptophan into kynurenine derivatives, which are involved in neural activity via the kynurenine pathway (KP). IDO1 is an initial rate-limiting enzyme in the KP and is activated by stress and/or inflammation. The perturbation of IDO1 activity, which causes KP imbalance, is associated with psychiatric and neurological disorders. It has...

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Source

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Identifiers

PMID: 30175526
DOI: 10.1002/npr2.12019
PMCID: PMC7292290

Genes

IDO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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