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Article

Genetic loss of D-amino acid oxidase activity reverses schizophrenia-like phenotypes in mice.

Genes, brain, and behavior - 1 Feb 2010

Labrie V, Wang W, Barger S W, Baker G B, Roder J C

Abstract excerpt

Reduced function of the N-methyl-d-aspartate receptor (NMDAR) has been implicated in the pathophysiology of schizophrenia. The NMDAR contains a glycine binding site in its NR1 subunit that may be a useful target for the treatment of schizophrenia. In this study, we assessed the therapeutic potential of long-term increases in the brain levels of the endogenous NMDAR glycine site agonist D-serine, through the...

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Identifiers

PMID: 19751394
DOI: 10.1111/j.1601-183X.2009.00529.x
PMCID: PMC2824030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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