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Article

Retinal NMDA receptor function and expression are altered in a mouse lacking D-amino acid oxidase.

Journal of neurophysiology - 1 Dec 2013

Gustafson Eric C, Morgans Catherine W, Tekmen Merve, Sullivan Steven J, Esguerra Manuel, Konno Ryuichi, Miller Robert F

Abstract excerpt

D-serine is present in the vertebrate retina and serves as a coagonist for the N-methyl-D-aspartate (NMDA) receptors of ganglion cells. Although the enzyme D-amino acid oxidase (DAO) has been implicated as a pathway for d-serine degradation, its role in the retina has not been established. In this study, we investigated the role of DAO in regulating D-serine levels using a mutant mouse line deficient in DAO...

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Identifiers

PMID: 24068757
DOI: 10.1152/jn.00310.2013
PMCID: PMC3882816

Genes

DAO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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