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Article

Subcellular trafficking signals of constitutive androstane receptor: evidence for a nuclear export signal in the DNA-binding domain.

Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 2007

Xia Jun, Kemper Byron

Abstract excerpt

Translocation of constitutive androstane receptor (CAR) from the cytoplasm to the nucleus is induced by phenobarbital-like drugs. Nuclear localization signals (NLSs) and a sequence [xenochemical response signal (XRS)] required for xenobiotic-induced nuclear translocation have been defined in rat...

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PMID: 17567731
DOI: 10.1124/dmd.107.016493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17567731-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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