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Article

Nuclear receptor-mediated regulation of carboxylesterase expression and activity

18 Feb 2010

Abstract excerpt

IMPORTANCE OF THE FIELD: Emerging evidence demonstrates that several nuclear receptor (NR) family members regulate drug-inducible expression and activity of several important carboxylesterase (CES) enzymes in mammalian liver and intestine. Numerous clinically prescribed anticancer prodrugs, carbamate and pyrethroid insecticides, environmental toxicants and procarcinogens are substrates for CES enzymes. Moreover,...

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PMID: 20163318
DOI: 10.1517/17425250903483215

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