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Article

An IFNG SNP with an estrogen-like response element selectively enhances promoter expression in peripheral but not lamina propria T cells.

Genes and immunity - 1 Jul 2006

Gonsky R, Deem R L, Bream J H, Young H A, Targan S R

Abstract excerpt

This study examines mucosa-specific regulatory pathways involved in modulation of interferon-gamma (IFN-gamma) in lamina propria T cells. Previous studies identified mucosa-specific CD2 cis-elements within the -204 to -108 bp IFNG promoter. Within this region, a single-site nucleotide polymorphism, -179G/T, imparts tumor necrosis factor-alpha stimulation of IFNG in peripheral blood lymphocytes, and is linked with...

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Share to Estrogens
Share to Interferon-gamma
Share to Leukocytes, Mononuclear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphocyte Activation

Share to Mucous Membrane

Share to Promoter Regions, Genetic

Share to Response Elements

Share to T-Lymphocytes

Source

Identifiers

PMID: 16724074
DOI: 10.1038/sj.gene.6364305

Genes

IFNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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