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Article

A single nucleotide polymorphism in the proximal IFN-gamma promoter alters control of gene transcription.

Genes and immunity - 1 May 2002

Bream J H, Ping A, Zhang X, Winkler C, Young H A

Abstract excerpt

Interferon-gamma (IFN-gamma) is an important cytokine that regulates cellular immune responses to intracellular pathogens and neoplasia. Regulation of IFN-gamma expression is stringently controlled at the transcriptional level. In this report we describe two novel single nucleotide polymorphisms (SNPs); one, at -179 in the promoter, occurs in 4% of African Americans. This SNP represents a guanidine to thymidine...

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Identifiers

PMID: 12070781
DOI: 10.1038/sj.gene.6363870

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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