Article
Cutting Edge: Genetic Association between IFI16 Single Nucleotide Polymorphisms and Resistance to Genital Herpes Correlates with IFI16 Expression Levels and HSV-2-Induced IFN-β Expression.
Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2017
Eriksson Kristina, Svensson Alexandra, Hait Alon S, Schlüter Kerstin, Tunbäck Petra, Nordström Inger, Padyukov Leonid, Liljeqvist Jan-Åke, Mogensen Trine H, Paludan Søren R
Abstract excerpt
IFN-γ-inducible protein 16 (IFI16) is an immunological DNA sensor proposed to act in the cyclic GMP-AMP synthase-stimulator of IFN genes pathway. Because mice do not have a clear ortholog of IFI16, this system is not suitable for genetic studies of IFI16. In this study, we have compared the dependency on IFI16, cyclic GMP-AMP synthase, and stimulator of IFN genes for type I IFN induction by a panel of pathogenic...
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