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Article

IFNL1 gene promoter single nucleotide polymorphism rs7247086 enhances transcription through a STAT-binding site.

Cytokine - 1 Nov 2026

Kaushik Sapana, Bharatiya Seema, Roy Debarati Guha, Panchariya Darshan, Roy Ahona, Raval Dhara, Mondal Avik, Palit Aparna, Chinnaswamy Sreedhar

Abstract excerpt

A single nucleotide polymorphism (SNP) within the human interferon lambda 1 (IFN-L1, IFN-λ1) gene promoter, rs7247086 (C/T) has been reported to be associated with severe dengue and possibly with psoriasis and COVID-19. However, its functional nature is unknown. The present study was undertaken to examine the effect of rs7247086 on transcription, by utilizing promoter and enhancer-reporter assays. We see that the...

Read the complete abstract on PubMed

Topics

Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

Binding Sites

Interferon Lambda

Female

Interleukins

Male

HEK293 Cells

Interferons

Transcription, Genetic

Alleles

STAT Transcription Factors

A549 Cells

Source

Identifiers

PMID: 42604633
DOI: 10.1016/j.cyto.2026.157200

Genes

IFNL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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