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Article

The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration.

Nature - 14 Feb 1991

Driscoll M, Chalfie M

Abstract excerpt

Three dominant mutations of mec-4, a gene needed for mechanosensation, cause the touch-receptor neurons of Caenorhabditis elegans to degenerate. With deg-1, another C. elegans gene that can mutate to induce neuronal degeneration and that is similar in sequence, mec-4 defines a new gene family. Cross-hybridizing sequences are detectable in other species, raising the possibility that degenerative conditions in...

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PMID: 1672038
DOI: 10.1038/349588a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration.PMID 1672038Read ↗

A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans.Semantic proximity Read ↗

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MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation.Semantic proximity Read ↗

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Spatial asymmetry in the mechanosensory phenotypes of the C. elegans DEG/ENaC gene mec-10.Semantic proximity Read ↗

Caenorhabditis elegans paraoxonase-like proteins control the functional expression of DEG/ENaC mechanosensory proteins.Semantic proximity Read ↗

Identification of genes expressed in C. elegans touch receptor neurons.Semantic proximity Read ↗

A stomatin-like protein necessary for mechanosensation in C. elegans.Semantic proximity Read ↗

MEC-2 is recruited to the putative mechanosensory complex in C. elegans touch receptor neurons through its stomatin-like domain.Semantic proximity Read ↗

Extracellular proteins organize the mechanosensory channel complex in C. elegans touch receptor neurons.Semantic proximity Read ↗

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