Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Extracellular proteins organize the mechanosensory channel complex in C. elegans touch receptor neurons.

Neuron - 2 Dec 2004

Emtage Lesley, Gu Guoqiang, Hartwieg Erika, Chalfie Martin

Abstract excerpt

Specialized extracellular matrix (ECM) is associated with virtually every mechanosensory system studied. C. elegans touch receptor neurons have specialized ECM and attach to the surrounding epidermis. The mec-1 gene encodes an ECM protein with multiple EGF and Kunitz domains. MEC-1 is needed for the accumulation of the collagen MEC-5 and other ECM components, attachment, and, separately, for touch sensitivity....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Collagen

Share to Epidermal Growth Factor

Share to Extracellular Matrix Proteins

Share to Mechanoreceptors

Share to Tissue Distribution

Source

Identifiers

PMID: 15572111
DOI: 10.1016/j.neuron.2004.11.010

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extracellular proteins organize the mechanosensory channel complex in C. elegans touch receptor neurons.PMID 15572111Read ↗

Molecules that mediate touch transduction in the nematode Caenorhabditis elegans.Semantic proximity Read ↗

Spatial asymmetry in the mechanosensory phenotypes of the C. elegans DEG/ENaC gene mec-10.Semantic proximity Read ↗

MEC-2 is recruited to the putative mechanosensory complex in C. elegans touch receptor neurons through its stomatin-like domain.Semantic proximity Read ↗

Touch receptor development and function in Caenorhabditis elegans.Semantic proximity Read ↗

Caenorhabditis elegans paraoxonase-like proteins control the functional expression of DEG/ENaC mechanosensory proteins.Semantic proximity Read ↗

The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals.Semantic proximity Read ↗

A stomatin-like protein necessary for mechanosensation in C. elegans.Semantic proximity Read ↗

MEC-10 and MEC-19 Reduce the Neurotoxicity of the MEC-4(d) DEG/ENaC Channel in Caenorhabditis elegans.Semantic proximity Read ↗

Extracellular matrix regulates morphogenesis and function of ciliated sensory organs in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Touch sensation in Caenorhabditis elegans.Semantic proximity Read ↗

Genetic interactions affecting touch sensitivity in Caenorhabditis elegans.Semantic proximity Read ↗

Combinatorial control of touch receptor neuron expression in Caenorhabditis elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.