Article
Identification of genes expressed in C. elegans touch receptor neurons.
Nature - 18 Jul 2002
Zhang Yun, Ma Charles, Delohery Thomas, Nasipak Brian, Foat Barrett C, Bounoutas Alexander, Bussemaker Harmen J, Kim Stuart K, Chalfie Martin
Abstract excerpt
The extent of gene regulation in cell differentiation is poorly understood. We previously used saturation mutagenesis to identify 18 genes that are needed for the development and function of a single type of sensory neuron--the touch receptor neuron for gentle touch in Caenorhabditis elegans. One of these genes, mec-3, encodes a transcription factor that controls touch receptor differentiation. By culturing and...
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