Article
Genetic mapping of new DNA probes at Xq27 defines a strategy for DNA studies in the fragile X syndrome.
American journal of human genetics - 1 Mar 1991
Suthers G K, Mulley J C, Voelckel M A, Dahl N, Väisänen M L, Steinbach P, Glass I A, Schwartz C E, van Oost B A, Thibodeau S N
Abstract excerpt
The fragile X syndrome is the most common cause of familial mental retardation and is characterized by a fragile site at the end of the long arm of the X chromosome. The unusual genetics and cytogenetics of this X-linked condition make genetic counseling difficult. DNA studies were of limited val...
Topics
- Chromosome Mapping
- DNA
- DNA Probes
- Fragile X Syndrome
- Genetic Linkage
- Humans
- Mutation
- Pedigree
- Polymorphism, Restriction Fragment Length
- Recombination, Genetic
- X Chromosome