Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fragile X syndrome: diagnosis using highly polymorphic microsatellite markers.

American journal of human genetics - 1 Jun 1991

Richards R I, Shen Y, Holman K, Kozman H, Hyland V J, Mulley J C, Sutherland G R

Abstract excerpt

We describe two highly polymorphic microsatellite AC repeat sequences, VK23AC and VK14AC, which are closely linked to the fragile X at Xq27.3. Both VK23AC (DXS297) and VK14AC (DXS292) are proximal to the fragile site. Two-point linkage analysis in 31 fragile X families gave (a) a recombination frequency of 1% (range 0.00%-4%) with a maximum lod score of 32.04 for DXS297 and (b) a recombination frequency of 7%...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Base Sequence
Share to DNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Linkage

Share to Genetic Markers

Share to Molecular Sequence Data

Share to Pedigree

Share to Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 2035525
PMCID: PMC1683096

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fragile X syndrome: diagnosis using highly polymorphic microsatellite markers.PMID 2035525Read ↗

A linkage map of microsatellite markers on the human X chromosome.Semantic proximity Read ↗

Genetic mapping of new DNA probes at Xq27 defines a strategy for DNA studies in the fragile X syndrome.Semantic proximity Read ↗

Genetic mapping of two new DNA markers in Xq26-q28 relative to the fragile-X syndrome locus.Semantic proximity Read ↗

DNA linkage analysis of 26 families with fragile X syndrome.Semantic proximity Read ↗

Isolation and characterization of a highly polymorphic human locus (DXS455) in proximal Xq28.Semantic proximity Read ↗

A high-density SNP map for the FRAX region of the X chromosome. Single-nucleotide polymorphisms.Semantic proximity Read ↗

A high-density single-nucleotide polymorphism map of Xq25-q28.Semantic proximity Read ↗

Physical mapping of new DNA probes near the fragile X mutation (FRAXA) by using a panel of cell lines.Semantic proximity Read ↗

Homologous loci DXYS156X and DXYS156Y contain a polymorphic pentanucleotide repeat (TAAAA)n and map to human X and Y chromosomes.Semantic proximity Read ↗

Allelic association in the FRAX region.Semantic proximity Read ↗

Validation of the X-chromosomal STR DXS6809.Semantic proximity Read ↗

Linkage disequilibrium between the fragile X mutation and two closely linked CA repeats suggests that fragile X chromosomes are derived from a small number of founder chromosomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.