Fragile X syndrome: diagnosis using highly polymorphic microsatellite markers.

Article

Fragile X syndrome: diagnosis using highly polymorphic microsatellite markers.

American journal of human genetics - 1 Jun 1991

Richards R I, Shen Y, Holman K, Kozman H, Hyland V J, Mulley J C, Sutherland G R

Abstract excerpt

We describe two highly polymorphic microsatellite AC repeat sequences, VK23AC and VK14AC, which are closely linked to the fragile X at Xq27.3. Both VK23AC (DXS297) and VK14AC (DXS292) are proximal to the fragile site. Two-point linkage analysis in 31 fragile X families gave (a) a recombination fr...

Topics

Alleles
Autoradiography
Base Sequence
DNA
DNA, Satellite
Fragile X Syndrome
Genetic Linkage
Genetic Markers
Humans
Lod Score
Molecular Sequence Data
Pedigree
Polymorphism, Genetic
Repetitive Sequences, Nucleic Acid

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.