Article
Isolation of sequences that span the fragile X and identification of a fragile X-related CpG island.
Science (New York, N.Y.) - 8 Mar 1991
Heitz D, Rousseau F, Devys D, Saccone S, Abderrahim H, Le Paslier D, Cohen D, Vincent A, Toniolo D, Della Valle G
Abstract excerpt
Yeast artificial chromosomes (YACs) were obtained from a 550-kilobase region that contains three probes previously mapped as very close to the locus of the fragile X syndrome. These YACs spanned the fragile site in Xq27.3 as shown by fluorescent in situ hybridization. An internal 200-kilobase seg...
Topics
- Base Sequence
- Chromosomes, Fungal
- Cloning, Molecular
- DNA Probes
- Dinucleoside Phosphates
- Fragile X Syndrome
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization
- Oligonucleotide Probes
- Polymerase Chain Reaction
- Reference Values
- Restriction Mapping