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Article

Isolation of sequences that span the fragile X and identification of a fragile X-related CpG island.

Science (New York, N.Y.) - 8 Mar 1991

Heitz D, Rousseau F, Devys D, Saccone S, Abderrahim H, Le Paslier D, Cohen D, Vincent A, Toniolo D, Della Valle G

Abstract excerpt

Yeast artificial chromosomes (YACs) were obtained from a 550-kilobase region that contains three probes previously mapped as very close to the locus of the fragile X syndrome. These YACs spanned the fragile site in Xq27.3 as shown by fluorescent in situ hybridization. An internal 200-kilobase segment contained four chromosomal breakpoints generated by induction of fragile X expression. A single CpG island was...

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Identifiers

PMID: 2006411
DOI: 10.1126/science.2006411

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Isolation of sequences that span the fragile X and identification of a fragile X-related CpG island.PMID 2006411Read ↗

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Physical mapping of new DNA probes near the fragile X mutation (FRAXA) by using a panel of cell lines.Semantic proximity Read ↗

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Genetic mapping of new DNA probes at Xq27 defines a strategy for DNA studies in the fragile X syndrome.Semantic proximity Read ↗

PCR amplification and analysis of yeast artificial chromosomes.Semantic proximity Read ↗

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome.Semantic proximity Read ↗

Linear order of new and established DNA markers around the fragile site at Xq27.3.Semantic proximity Read ↗

Isolation of a GCC repeat showing expansion in FRAXF, a fragile site distal to FRAXA and FRAXE.Semantic proximity Read ↗

Molecular characterization of a DNA probe, U6.2, located close to the fragile X locus.Semantic proximity Read ↗

Fragile X genotype characterized by an unstable region of DNA.Semantic proximity Read ↗

Deletions in Xq26.3-q27.3 including FMR1 result in a severe phenotype in a male and variable phenotypes in females depending upon the X inactivation pattern.Semantic proximity Read ↗

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