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Article

Immunosenescence phenotypes in the telomerase knockout mouse.

Springer seminars in immunopathology - 1 Jan 2002

Blasco María A

Abstract excerpt

Increasing generations of the telomerase knockout mouse, Terc-/-, show severe telomere dysfunction characterized by critically short telomeres and end-to-end chromosomal fusions. These mice also suffer from various age-related diseases affecting highly proliferative tissues. Among these pathologies are a reduced proliferative capacity of B and T cells, as well as a reduction of germinal center reactivity upon...

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Identifiers

PMID: 11974584
DOI: 10.1007/s00281-001-0096-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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