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Article

Genetic variation and recent positive selection in worldwide human populations: evidence from nearly 1 million SNPs.

PloS one - 18 Nov 2009

López Herráez David, Bauchet Marc, Tang Kun, Theunert Christoph, Pugach Irina, Li Jing, Nandineni Madhusudan R, Gross Arnd, Scholz Markus, Stoneking Mark

Abstract excerpt

BACKGROUND: Genome-wide scans of hundreds of thousands of single-nucleotide polymorphisms (SNPs) have resulted in the identification of new susceptibility variants to common diseases and are providing new insights into the genetic structure and relationships of human populations. Moreover, genome-wide data can be used to search for signals of recent positive selection, thereby providing new insights into the...

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PMID: 19924308
DOI: 10.1371/journal.pone.0007888
PMCID: PMC2775638

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