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Article

Enhanced accumulation of tau in doubly transgenic mice expressing mutant betaAPP and presenilin-1.

Brain research - 13 Jun 2006

Samura Eriko, Shoji Mikio, Kawarabayashi Takeshi, Sasaki Atsushi, Matsubara Etsuro, Murakami Tetsuro, Wuhua Xu, Tamura Shuta, Ikeda Masaki, Ishiguro Koich, Saido Takaomi C, Westaway David, St George Hyslop Peter, Harigaya Yasuo, Abe Koji

Abstract excerpt

Abeta amyloidosis and tauopathy are characteristic changes in the brain of Alzheimer's disease. Although much evidence suggests that Abeta deposit is a critical initiation factor, the pathological pathway between Abeta amyloidosis and tau accumulation remains unclear. Tau accumulation was examined in the doubly transgenic mouse (APP-PS) expressing betaAPP(KM670/671NL) (Tg2576) and presenilin-1 L286V (PS-1...

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Source

Identifiers

PMID: 16713590
DOI: 10.1016/j.brainres.2005.12.134

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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