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Article

Characterization of a double (amyloid precursor protein-tau) transgenic: tau phosphorylation and aggregation.

Neuroscience - 1 Jan 2005

Pérez M, Ribe E, Rubio A, Lim F, Morán M A, Ramos P Gómez, Ferrer I, Isla M T G, Avila J

Abstract excerpt

A double transgenic mouse expressing the amyloid precursor protein, bearing the Swedish mutations, and expressing tau protein containing three of the mutations present in frontotemporal dementia linked to chromosome 17 (FTDP-17), has been characterized. In the double transgenic mouse an increase in tau phosphorylation at serine S262 and S422 was observed compared with that found in simple transgenic mice. The...

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Source

Identifiers

PMID: 15664690
DOI: 10.1016/j.neuroscience.2004.09.029

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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