Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes.

doi:10.1038/nm0198-097

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Article

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes.

Nature medicine - 1 Jan 1998

Holcomb L, Gordon M N, McGowan E, Yu X, Benkovic S, Jantzen P, Wright K, Saad I, Mueller R, Morgan D, Sanders S, Zehr C, O'Campo K, Hardy J, Prada C M, Eckman C, Younkin S, Hsiao K, Duff K

Abstract excerpt

Genetic causes of Alzheimer's disease (AD) include mutations in the amyloid precursor protein (APP), presenilin 1 (PS1), and presenilin 2 (PS2) genes. The mutant APP(K670N,M671L) transgenic line, Tg2576, shows markedly elevated amyloid beta-protein (A beta) levels at an early age and, by 9-12 mon...

Topics

Alzheimer Disease
Amyloid beta-Protein Precursor
Analysis of Variance
Animals
Brain
Cerebral Cortex
Crosses, Genetic
Genotype
Glial Fibrillary Acidic Protein
Humans
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Transgenic

Motor Activity

Posture

Presenilin-1

Psychomotor Performance

Reflex

Source

Open in PubMed

Identifiers

PMID: 9427614
DOI: 10.1038/nm0198-097

Genes

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9427614-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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