Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neurofibrillary pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.

Journal of neuropathology and experimental neurology - 1 Apr 2001

Masliah E, Sisk A, Mallory M, Games D

Abstract excerpt

Overexpression of mutated human amyloid precursor protein (hAPP717V-->F) under control of the platelet-derived growth factor promoter (PDAPP minigene) in transgenic (tg) mice results in plaque formation and astroglial activation similar to Alzheimer disease (AD). However, the extent of the neurofibrillary pathology in this model is less understood. In order to determine if these mice develop AD-like...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Protein Precursor
Share to Axons
Share to Cytoskeleton

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Frontal Lobe

Share to Microscopy, Immunoelectron

Share to Neurites

Share to Neurofibrillary Tangles

Share to tau Proteins

Source

Identifiers

PMID: 11305871
DOI: 10.1093/jnen/60.4.357

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neurofibrillary pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.PMID 11305871Read ↗

Enhanced accumulation of tau in doubly transgenic mice expressing mutant betaAPP and presenilin-1.Semantic proximity Read ↗

Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.Semantic proximity Read ↗

Anti-Aβ antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic miceSemantic proximity Read ↗

Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau.Semantic proximity Read ↗

Biochemical and morphological characterization of the AβPP/PS/tau triple transgenic mouse model and its relevance to sporadic Alzheimer's disease.Semantic proximity Read ↗

Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse modelSemantic proximity Read ↗

Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation.Semantic proximity Read ↗

Tau filament formation in transgenic mice expressing P301L tau.Semantic proximity Read ↗

Neuroanatomical Abnormalities in Behaviorally Characterized APPV717F Transgenic MiceSemantic proximity Read ↗

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.Semantic proximity Read ↗

Ultrastructural neuronal pathology in transgenic mice expressing mutant (P301L) human tau.Semantic proximity Read ↗

APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.