Article
Amyloid generation and dysfunctional immunoproteasome activation with disease progression in animal model of familial Alzheimer's disease.
Brain pathology (Zurich, Switzerland) - 1 Sept 2012
Aso Ester, Lomoio Selene, López-González Irene, Joda Laura, Carmona Margarita, Fernández-Yagüe Núria, Moreno Jesús, Juvés Salvador, Pujol Aurora, Pamplona Reinald, Portero-Otin Manuel, Martín Virginia, Díaz Mario, Ferrer Isidro
Abstract excerpt
Double-transgenic amyloid precursor protein/presenilin 1 (APP/PS1) mice express a chimeric mouse/human APP bearing the Swedish mutation (Mo/HuAPP695swe) and a mutant human PS1-dE9 both causative of familial Alzheimer's disease (FAD). Transgenic mice show impaired memory and learning performance from the age of 6 months onwards. Double-transgenic APP/PS1 mice express altered APP and PS1 mRNAs and proteins, reduced...
Topics
- Age Factors
- Alzheimer Disease
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Animals
- Aspartic Acid Endopeptidases
- Avoidance Learning
- Brain
- Cognition Disorders