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Amplification and molecular cloning of the IMP dehydrogenase gene of Leishmania donovani

1 Jan 1991

Abstract excerpt

A mutant (MPA100) strain of Leishmania donovania was generated from a wild type (D1700) population by virtue of its ability to survive the selective pressure of gradually increasing concentrations of mycophenolic acid (MPA), an inhibitor of IMP dehydrogenase (IMPDH) activity. Comparative growth experiments revealed that the MPA100 strain was 100-fold more resistant to MPA toxicity and cross-resistant to...

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PMID: 1671039
DOI: 10.1016/s0021-9258(18)52346-2

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