Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Screening the yeast "disruptome" for mutants affecting resistance to the immunosuppressive drug, mycophenolic acid.

The Journal of biological chemistry - 26 Jul 2002

Desmoucelles Christine, Pinson Benoit, Saint-Marc Christelle, Daignan-Fornier Bertrand

Abstract excerpt

The immunosuppressive drug mycophenolic acid (MPA) is a potent and specific inhibitor of IMP dehydrogenase, the first committed step of GMP synthesis. A screen for yeast genes affecting MPA sensitivity, when overexpressed, allowed us to identify two genes, IMD2 and TPO1, encoding a homologue of IMP dehydrogenase and a vacuolar pump, respectively. In parallel, 4787 yeast strains, each carrying an identified...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Northern
Share to Drug Resistance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Inhibitors

Share to Immunosuppressive Agents

Share to Mycophenolic Acid

Share to Open Reading Frames

Share to Plasmids

Share to Transgenes

Source

Identifiers

PMID: 12016207
DOI: 10.1074/jbc.M111433200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Screening the yeast "disruptome" for mutants affecting resistance to the immunosuppressive drug, mycophenolic acid.PMID 12016207Read ↗

Phenotypic consequences of purine nucleotide imbalance in Saccharomyces cerevisiae.Semantic proximity Read ↗

Large-scale screening of yeast mutants for sensitivity to the IMP dehydrogenase inhibitor 6-azauracil.Semantic proximity Read ↗

Regulation of an IMP dehydrogenase gene and its overexpression in drug-sensitive transcription elongation mutants of yeast.Semantic proximity Read ↗

Profiling the compendium of changes in Saccharomyces cerevisiae due to mutations that alter availability of the main methyl donor S-Adenosylmethionine.Semantic proximity Read ↗

Metabolic control of antifungal drug resistance.Semantic proximity Read ↗

Identification of genes differentially expressed in association with reduced azole susceptibility in Saccharomyces cerevisiae.Semantic proximity Read ↗

Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast.Semantic proximity Read ↗

The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components.Semantic proximity Read ↗

Tracing the Origin and Evolution of the Fungal Mycophenolic Acid Biosynthesis PathwaySemantic proximity Read ↗

Ubiquitin pathway proteins influence the mechanism of action of the novel immunosuppressive drug FTY720 in Saccharomyces cerevisiae.Semantic proximity Read ↗

Sinefungin resistance of Saccharomyces cerevisiae arising from Sam3 mutations that inactivate the AdoMet transporter or from increased expression of AdoMet synthase plus mRNA cap guanine-N7 methyltransferase.Semantic proximity Read ↗

Genetic, biochemical, and transcriptional responses of Saccharomyces cerevisiae to the novel immunomodulator FTY720 largely mimic those of the natural sphingolipid phytosphingosine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.