Article
Characterization of amplicons that suppress the conditional lethal growth phenotype of a Leishmania donovani mutant lacking normal purine salvage mechanisms.
Molecular and biochemical parasitology - 1 Jan 2011
Fulwiler Audrey L, Boitz Jan M, Yates Phillip A, Carter Nicola S, Ullman Buddy
Abstract excerpt
A conditionally lethal mutant of Leishmania donovani that lacks both hypoxanthine-guanine phosphoribosyltransferase and xanthine phosphoribosyltransferase exhibits a strikingly restricted growth phenotype, can only survive as the promastigote under pharmacological constraints, and is profoundly compromised in its ability to infect macrophages and mice. Interestingly, the conditionally lethal growth phenotype...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.