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Article

Molecular characterization of the ldmdr1 multidrug resistance gene from Leishmania donovani.

Molecular and biochemical parasitology - 1 Jul 1993

Hendrickson N, Sifri C D, Henderson D M, Allen T, Wirth D F, Ullman B

Abstract excerpt

The ldmdr1 gene that confers resistance to multiple structurally dissimilar hydrophobic drugs in Leishmania donovani has been isolated within a 5.4-kb XmaI fragment from a genomic library of L. donovani DNA and its protein coding region sequenced. The longest open reading frame within ldmdr1 encodes a 146.5-kDa protein of 1341 amino acids, designated LDMDR1. The primary structure and predicted membrane topology...

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PMID: 8103567
DOI: 10.1016/0166-6851(93)90028-v

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