Article
Molecular characterization of the ldmdr1 multidrug resistance gene from Leishmania donovani.
Molecular and biochemical parasitology - 1 Jul 1993
Hendrickson N, Sifri C D, Henderson D M, Allen T, Wirth D F, Ullman B
Abstract excerpt
The ldmdr1 gene that confers resistance to multiple structurally dissimilar hydrophobic drugs in Leishmania donovani has been isolated within a 5.4-kb XmaI fragment from a genomic library of L. donovani DNA and its protein coding region sequenced. The longest open reading frame within ldmdr1 enco...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Carrier Proteins
- DNA, Protozoan
- Drug Resistance, Microbial
- Gene Amplification
- Genes, Protozoan
- Leishmania donovani
- Membrane Glycoproteins
- Molecular Sequence Data
- Multigene Family
- Protein Structure, Secondary
- Protozoan Proteins
- Sequence Homology, Amino Acid