Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational landscape in genetically engineered, carcinogen-induced, and radiation-induced mouse sarcoma

21 May 2019

Abstract excerpt

Cancer development is influenced by hereditary mutations, somatic mutations due to random errors in DNA replication, or external factors. It remains unclear how distinct cell-intrinsic and -extrinsic factors impact oncogenesis within the same tissue type. We investigated murine soft tissue sarcomas generated by oncogenic alterations (KrasG12D activation and p53 deletion), carcinogens (3-methylcholanthrene [MCA]...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Hippo pathway signaling and YAP/TAZ
Share to Sarcoma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31112524
DOI: 10.1172/jci.insight.128698

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational landscape in genetically engineered, carcinogen-induced, and radiation-induced mouse sarcomaPMID 31112524Read ↗

Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma.Semantic proximity Read ↗

Mutational Analysis of Ionizing Radiation Induced Neoplasms.Semantic proximity Read ↗

Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma.Semantic proximity Read ↗

Mutations, Bottlenecks, and Clonal Sweeps: How Environmental Carcinogens and Genomic Changes Shape Clonal Evolution during Tumor Progression.Semantic proximity Read ↗

Genetic and environmental reprogramming of the sarcoma epigenome.Semantic proximity Read ↗

Genetic background sets the trajectory of cancer evolutionSemantic proximity Read ↗

Murine osteosarcoma recapitulates the driver landscape and genomic complexity of osteosarcoma evolution in humansSemantic proximity Read ↗

Enhancing radiotherapy response via intratumoral injection of the TLR9 agonist CpG to stimulate CD8 T cells in an autochthonous mouse model of sarcomaSemantic proximity Read ↗

Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers.Semantic proximity Read ↗

The mutational landscapes of genetic and chemical models of Kras-driven lung cancer.Semantic proximity Read ↗

Comprehensive Analysis of Hypermutation in Human Cancer.Semantic proximity Read ↗

Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.