Cancer as a complex genetic trait: tumor susceptibility in humans and mouse models.

doi:10.1016/s0092-8674(02)00622-0

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Article

Cancer as a complex genetic trait: tumor susceptibility in humans and mouse models.

Cell - 25 Jan 2002

Balmain Allan

Abstract excerpt

Cancer directly affects at least one-third of the human population, but the inherited genetic determinants of cancer risk remain largely unknown. Mouse models of human cancer are helping us to understand this disease as a complex genetic trait and thus to identify the multiple genetic variant alleles involved in pathways that affect individual cancer susceptibility.

Topics

Alleles
Animals
Disease Models, Animal
Genetic Predisposition to Disease
Humans
Mice
Models, Biological
Neoplasms
Quantitative Trait, Heritable
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 11832205
DOI: 10.1016/s0092-8674(02)00622-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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