Article
C-terminal nucleophosmin mutations are uncommon in chronic myeloid disorders.
British journal of haematology - 1 Jun 2006
Caudill Jonathan S C, Sternberg Alexander J, Li Chin-Yang, Tefferi Ayalew, Lasho Terra L, Steensma David P
Abstract excerpt
C-terminal somatic mutations in nucleophosmin (NPM), a nucleolar shuttling protein that binds p53 and p19(Arf), were recently described in karyotypically normal acute myeloid leukaemia (AML). We analysed primary marrow samples from 150 patients with various chronic myeloid disorders for mutations in the NPM1 gene encoding NPM. NPM1 mutations (tetranucleotide duplication) were detected in three patients, all of...
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