Article
Neurotransmitter phenotype-specific expression changes in developing sympathetic neurons.
Molecular and cellular neurosciences - 1 Jul 2007
Apostolova Galina, Dorn Roland, Ka Sojeong, Hallböök Finn, Lundeberg Joakim, Liser Keren, Hakim Vicky, Brodski Claude, Michaelidis Theologos M, Dechant Georg
Abstract excerpt
During late developmental phases individual sympathetic neurons undergo a switch from noradrenergic to cholinergic neurotransmission. This phenomenon of plasticity depends on target-derived signals in vivo and is triggered by neurotrophic factors in neuronal cultures. To analyze genome-wide expression differences between the two transmitter phenotypes we employed DNA microarrays. RNA expression profiles were...
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