Neocortical neurons lacking the protein-tyrosine kinase B receptor display abnormal differentiation and process elongation in vitro and in vivo.

doi:10.1016/s0306-4522(00)00106-8

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Article

Neocortical neurons lacking the protein-tyrosine kinase B receptor display abnormal differentiation and process elongation in vitro and in vivo.

Neuroscience - 1 Jan 2000

Gates M A, Tai C C, Macklis J D

Abstract excerpt

The spatial and temporal expression of the protein-tyrosine kinase B (TrkB) receptor and its ligands has been correlated with the development of the neocortex. Activation of the receptor has been associated with neocortical neuronal survival, differentiation, connectivity and neurotransmitter rel...

Topics

Animals
Brain Tissue Transplantation
Carbocyanines
Cell Differentiation
Cell Size
Cell Survival
Cells, Cultured
Cerebral Ventricles
Corpus Callosum
Female
Fluorescent Dyes
Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

In Vitro Techniques

Male

Mice

Mice, Knockout

Neocortex

Source

Open in PubMed

Identifiers

PMID: 10869838
DOI: 10.1016/s0306-4522(00)00106-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-10869838-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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