Article
The BAG2 protein stabilises PINK1 by decreasing its ubiquitination.
Biochemical and biophysical research communications - 15 Nov 2013
Che Xiangqian, Tang Beisha, Wang Xuejing, Chen Dong, Yan Xinxiang, Jiang Hong, Shen Lu, Xu Qian, Wang Guanghui, Guo Jifeng
Abstract excerpt
Mutations in the PTEN-induced putative kinase 1 (PINK1) gene cause an autosomal recessive form of Parkinson disease (PD). Thus far, little is known about what can regulate the ubiquitin proteasome pathway of PINK1. Here, we report BAG2 (Bcl-2-associated athanogene family protein 2), a member of the BAG family, which directly binds with and stabilises PINK1 by decreasing its ubiquitination. Moreover, we found that...
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