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Article

The tuberous sclerosis genes and regulation of the cyclin-dependent kinase inhibitor p27.

Mutation research - 1 Sept 2006

Rosner Margit, Freilinger Angelika, Hengstschläger Markus

Abstract excerpt

Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome that affects approximately 1 in 6000 individuals. It is characterized by the development of tumors, named hamartomas, in the kidneys, heart, skin and brain. The latter often cause seizures, mental retardation, and a variety of developmental disorders, including autism. This disease is caused by mutations within the tumor suppressor gene TSC1...

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Source

Identifiers

PMID: 16713332
DOI: 10.1016/j.mrrev.2006.03.001

Genes

TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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