Article
CYP17 genotype modifies the association between lignan supply and premenopausal breast cancer risk in humans.
The Journal of nutrition - 1 Jun 2006
Piller Regina, Verla-Tebit Emaculate, Wang-Gohrke Shan, Linseisen Jakob, Chang-Claude Jenny
Abstract excerpt
Cytochrome P450c17alpha (CYP17) has been associated with alterations in steroid hormone levels and premenopausal breast cancer risk and could modify the association between phytoestrogen intake and breast cancer risk. We examined plasma concentrations of enterolactone and genistein, estimated dietary phytoestrogen intake, CYP17 5'-UTR MspA1 genetic polymorphism, and breast cancer risk in 267 premenopausal breast...
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