Article
Estrogen-biosynthesis gene CYP17 and its interactions with reproductive, hormonal and lifestyle factors in breast cancer risk: results from the Long Island Breast Cancer Study Project.
Carcinogenesis - 1 Apr 2008
Chen Yu, Gammon Marilie D, Teitelbaum Susan L, Britton Julie A, Terry Mary Beth, Shantakumar Sumitra, Eng Sybil M, Wang Qiao, Gurvich Irina, Neugut Alfred I, Santella Regina M, Ahsan Habibul
Abstract excerpt
The genes that are involved in estrogen biosynthesis, cellular binding and metabolism may contribute to breast cancer susceptibility. We examined the effect of the CYP17 promoter T --> C polymorphism and its interactions with the reproductive history, exogenous hormone use and selected lifestyle risk factors on breast cancer risk among 1037 population-based incident cases and 1096 population-based controls in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.