Article
Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination.
PLoS biology - 1 Jun 2006
Kim Yuna, Kobayashi Akio, Sekido Ryohei, DiNapoli Leo, Brennan Jennifer, Chaboissier Marie-Christine, Poulat Francis, Behringer Richard R, Lovell-Badge Robin, Capel Blanche
Abstract excerpt
The genes encoding members of the wingless-related MMTV integration site (WNT) and fibroblast growth factor (FGF) families coordinate growth, morphogenesis, and differentiation in many fields of cells during development. In the mouse, Fgf9 and Wnt4 are expressed in gonads of both sexes prior to sex determination. Loss of Fgf9 leads to XY sex reversal, whereas loss of Wnt4 results in partial testis development in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.