Article
A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse.
Nature genetics - 1 Dec 2000
Bishop C E, Whitworth D J, Qin Y, Agoulnik A I, Agoulnik I U, Harrison W R, Behringer R R, Overbeek P A
Abstract excerpt
In most mammals, male development is triggered by the transient expression of the Y-chromosome gene, Sry, which initiates a cascade of gene interactions ultimately leading to the formation of a testis from the indifferent fetal gonad. Several genes, in particular Sox9, have a crucial role in this pathway. Despite this, the direct downstream targets of Sry and the nature of the pathway itself remain to be clearly...
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