Sex determination and the control of Sox9 expression in mammals

Abstract excerpt

In mouse sex determination, the presence or absence of Sertoli cells in the developing gonad is essential for the decision to form either a testis or an ovary. The transcription factor SOX9 has emerged as the master regulator of Sertoli cell differentiation during testis development and thus the crucial gene to determine sex. It is the target of two sets of regulatory controls, one positive and one negative,...

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• Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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