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WNT4 and Sex Development

1 Jan 2008

Abstract excerpt

Although factors involved in male sexual differentiation have been well studied, the pathways regulating female sexual differentiation remain incompletely defined. To date, no genes have been identified to play a similar role in ovarian development as was shown for the SRY or SOX9 genes in testicular development. In mice, Wnt4 regulates the development of the female reproductive tract, antagonizes the production...

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PMID: 18987495
DOI: 10.1159/000152037

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