Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Turning on the male--SRY, SOX9 and sex determination in mammals.

Cytogenetic and genome research - 1 Jan 2003

Knower K C, Kelly S, Harley V R

Abstract excerpt

The decision of the bi-potential gonad to develop into either a testis or ovary is determined by the presence or absence of the Sex-determining Region gene on the Y chromosome (SRY). Since its discovery, almost 13 years ago, the molecular role that SRY plays in initiating the male sexual development cascade has proven difficult to ascertain. While biochemical studies of clinical mutants and mouse genetic models...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Binding Proteins
Share to Genes, sry
Share to High Mobility Group Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mammals

Share to Nuclear Proteins

Share to Sex Determination Processes

Share to Sex-Determining Region Y Protein

Share to SOX9 Transcription Factor

Source

Identifiers

PMID: 14684982
DOI: 10.1159/000074336

Genes

SRY
SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Turning on the male--SRY, SOX9 and sex determination in mammals.PMID 14684982Read ↗

Sex with two SOX on: SRY and SOX9 in testis development.Semantic proximity Read ↗

Male sex determination: insights into molecular mechanismsSemantic proximity Read ↗

Diverse Regulation but Conserved Function: SOX9 in Vertebrate Sex DeterminationSemantic proximity Read ↗

SRY and the Standoff in Sex DeterminationSemantic proximity Read ↗

<i>Sry</i>: the master switch in mammalian sex determinationSemantic proximity Read ↗

SOX Genes and Their Role in Disorders of Sex DevelopmentSemantic proximity Read ↗

The Molecular Action and Regulation of the Testis-Determining Factors, SRY (Sex-Determining Region on the Y Chromosome) and SOX9 [SRY-Related High-Mobility Group (HMG) Box 9]Semantic proximity Read ↗

Sex Determination and Gonadal Development in MammalsSemantic proximity Read ↗

SEX IN THE 90s:<i>SRY</i>and the Switch to the Male PathwaySemantic proximity Read ↗

Interactions between SRY and SOX genes in mammalian sex determinationSemantic proximity Read ↗

Influence on spatiotemporal patterns of a male-specific Sox9 activation by ectopic Sry expression during early phases of testis differentiation in miceSemantic proximity Read ↗

Sry and SoxE genes: How they participate in mammalian sex determination and gonadal development?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.