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Article

Stabilization of beta-catenin in XY gonads causes male-to-female sex-reversal.

Human molecular genetics - 1 Oct 2008

Maatouk Danielle M, DiNapoli Leo, Alvers Ashley, Parker Keith L, Taketo Makoto M, Capel Blanche

Abstract excerpt

During mammalian sex determination, expression of the Y-linked gene Sry shifts the bipotential gonad toward a testicular fate by upregulating a feed-forward loop between FGF9 and SOX9 to establish SOX9 expression in somatic cells. We previously proposed that these signals are mutually antagonisti...

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Share to beta Catenin
Share to Disorders of Sex Development
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Testis

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Share to Wnt4 Protein

Source

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Identifiers

PMID: 18617533
DOI: 10.1093/hmg/ddn193
PMCID: PMC2536503

Genes

RSPO1
SOX9
WNT4
FGF9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18617533-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Stabilization of beta-catenin in XY gonads causes male-to-female sex-reversal.PMID 18617533Read ↗

SRY and the Standoff in Sex DeterminationSemantic proximity Read ↗

R-spondin1, WNT4, and the CTNNB1 signaling pathway: strict control over ovarian differentiationSemantic proximity Read ↗

Activation of -catenin signaling by Rspo1 controls differentiation of the mammalian ovarySemantic proximity Read ↗

Sox8 and Sox9 act redundantly for ovarian-to-testicular fate reprogramming in the absence of R-spondin1 in mouse sex reversalsSemantic proximity Read ↗

Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination.Semantic proximity Read ↗

Turning on the male--SRY, SOX9 and sex determination in mammals.Semantic proximity Read ↗

<i>Sry</i>: the master switch in mammalian sex determinationSemantic proximity Read ↗

Determination and Stability of Gonadal SexSemantic proximity Read ↗

Sex-specific roles of -catenin in mouse gonadal developmentSemantic proximity Read ↗

Loss of Wnt4 and Foxl2 leads to female-to-male sex reversal extending to germ cellsSemantic proximity Read ↗

Testicular Differentiation Occurs in Absence of R-spondin1 and Sox9 in Mouse Sex ReversalsSemantic proximity Read ↗

<i>Sox8</i> and <i>Sox9</i> act redundantly for ovarian-to-testicular fate reprogramming in the absence of <i>R-spondin1</i> in mouse sex reversalsSemantic proximity Read ↗

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