Article
Stabilization of beta-catenin in XY gonads causes male-to-female sex-reversal.
Human molecular genetics - 1 Oct 2008
Maatouk Danielle M, DiNapoli Leo, Alvers Ashley, Parker Keith L, Taketo Makoto M, Capel Blanche
Abstract excerpt
During mammalian sex determination, expression of the Y-linked gene Sry shifts the bipotential gonad toward a testicular fate by upregulating a feed-forward loop between FGF9 and SOX9 to establish SOX9 expression in somatic cells. We previously proposed that these signals are mutually antagonistic with counteracting signals in XX gonads and that a shift in the balance of these factors leads to either male or...
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